Abstract
The effect of psychostimulants on relearning of the avoidance direction by rats in a Y-maze was assessed. The effects were analyzed vectorographically with absolute and relative values for the main response indices. In both cases the behavior profile of the group of animals was traced. Sydnocarb (20 mg/kg) gave the optimal effect, for unlike caffeine (25 mg/kg) and amphetamine (0.5 mg/kg), it not only stimulated active avoidance but also improved relearning by the animals. An increase in the dose of sydnocarb to 50 mg/kg did not disturb the rats' behavior, whereas caffeine (50 mg/kg) and, in particular, amphetamine (5 mg/kg) disturbed behavior. The behavior profile after amphetamine went far beyond the bounds of the original level and was characterized by marked worsening of passive avoidance.
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Arushanyan, É.B., Baturin, V.A. Vectorographic assessment of the effect of psychostimulants on avoidance behavior in rats. Bull Exp Biol Med 84, 1277–1280 (1977). https://doi.org/10.1007/BF00805883
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DOI: https://doi.org/10.1007/BF00805883