Abstract
A biochemical, histological, and histochemical study was made of the effect of contrykal, an inhibitor of proteolytic enzymes, on the healing of experimental burn wounds in rats. Healing of burn wounds (flame burns covering 20% of the body surface) in animals untreated with contrykal was found to be accompanied by the development of secondary necrosis, by a marked inflammatory reaction, and by increased activity of certain proteases and peptidases. Administration of contrykal prevented the development of secondary necrosis, which is evidently associated with a reduction in the activity of the tissue proteolytic enzymes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
A. N. Alekseenko in: Modern Methods in Biochemistry [in Russian], Vol. 2, Moscow (1968), p. 115.
T. L. Zaets M. I. Dolgina, L. I. Muzykant, et al., Éksp. Khir., No. 5 49 (1974).
T. L. Zaets and M. A. Zaidenberg, Patol. Fiziol., No. 5, 2 (1974).
A. Beloff and R. Peters, J. Physiol. (London),103 461 (1945).
W. Greuer, Dtsch. Med. Wschr,74 1205 (1949).
L. Kozlowski and L. Kilninger, in: Third International Congress on Research in Burns, Abstract, Bern (1971), p. 144.
L. Lewis, J. Peters, and A. White, Br. J. Pharmacol.,42, 437 (1971).
M. Malik, Br. J. Pathol.,52 345 (1971).
J. Niedworor and E. Spychalski, Acta Physiol Pol.,23, 987 (1972).
E. Werle, J. Trauschold, and H. Haendle, Ann. N. Y. Acad. Sci.,146, 464, (1918).
F. Wroblewski and J. S. La Due, Proc. Soc. Exp. Biol. (New York),90, 210 (1955).
W. Zietkiewierz, Pol Tyg. Lek.,27 557 (1972).
Rights and permissions
About this article
Cite this article
Muzykant, L.I., Zaets, T.L., Dolgina, M.I. et al. Inhibitors of trypsin-like proteolytic enzymes as substances preventing the development of secondary necrosis in burn wounds. Bull Exp Biol Med 84, 1257–1261 (1977). https://doi.org/10.1007/BF00805877
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00805877