Abstract
The state of the lung surfactant in rabbits at different stages of development of experimental pneumonia (3–60 days) was compared with the dynamics of oxidoreductases in the alveolar epithelium and cells of the inflammatory focus of infiltration. In the initial stage (3–7 days) of activation of cell metabolism there was a brief increase in, the intensity of surfactant lipid synthesis, accompanied by relative inhibition of phospholipid synthesis. Later, development of degenerative changes and sclerosis of the parenchyma was accompanied by inhibition of synthesis of all components of the surfactant. The surface activity of the surfactant became stabilized at a low level.
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Literature Cited
M. V. Barinova, “The state of the surfactant under certain experimental conditions and in chronic nonspecific diseases of the human lungs”, Author's Abstract of Candidate's Dissertation, Moscow (1971).
I. S. Bubnova, in: Current Problems in Pulmonology [in Russian], Leningrad (1975), pp. 58–60.
A. M. Zakhar'evskaya and I. N. Anichkov, Byull. Éksp. Biol. Med., No. 6, 62 (1952).
G. N. Dudnikova, Byull. Éksp. Biol. Med., No. 2, 17 (1973).
E. N. Nesterov, G. V. Kobozev, and G. A. Zavarzina, Byull. Éksp. Biol. Med., No. 2, 120 (1974).
M. Abrams, J. Appl. Physiol.,21, 718 (1966).
A. Galowaisky and S. Giammona, Am. Rev. Resp. Dis.,2, 336 (1972).
E. M. Scarpèlli, Triangle,10, 47 (1971).
V. Somerson et al., Science,171, 66 (1971).
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Panevskaya, G.N., Yashchenko, L.V., Nesterov, E.N. et al. Changes in state of the surfactant in experimental pneumonia. Bull Exp Biol Med 84, 1255–1257 (1977). https://doi.org/10.1007/BF00805876
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DOI: https://doi.org/10.1007/BF00805876