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Effect of parasympathetic acceleration on bioelectrical activity of pacemaker cells of the desympathized and reserpinized frog heart

  • Pathological Physiology and General Pathology
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Abstract

The mechanisms of parasympathetic acceleration was studied in experiments on the heart ofRana temporaria after preliminary exhaustion of the catecholamine reserves by desympathization and reserpinization of the animals. Electrical activity of cells of the isolated pacemaker was recorded. During parasympathetic acceleration the rate of rise of slow diastolic depolarization was found to increase (evidence of the active mechanism of this acceleration), and this was accompanied by slight hyperpolarization and by shortening of the duration of the action potential. After treatment of the preparation with atropine the accelerating effect and the changes in shape of the action potential disappeared, confirming the cholinergic nature of the parasympathetic acceleration. It is suggested that acetylcholine, the mediator of the parasympathetic system, may reduce potassium or increase sodium permeability of the pacemaker cell membrane, thus increasing the rate of rise of slow diastolic depolarization and causing acceleration of discharges.

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Literature Cited

  1. N. A. Sokolova, “Organization of parasympathetic inhibitory and accelerating influences in extracardiac pathways and in the intracardiac nervous system,” Author's Abstract of Candidate's Dissertation, Moscow (1974).

  2. M. G. Udel'nov, The Nervous Regulation of the Heart [in Russian], Moscow (1961).

  3. M. G. Udel'nov, Physiology of the Heart [in Russian], Moscow (1975).

  4. M. G. Udel'nov, N. A. Sokolova, and G. N. Kopylova, Usp. Fiziol. Nauk, No. 1, 19 (1977).

    Google Scholar 

  5. E. T. Angelakos, F. M. Glassman, R. M. Millard, et al., Comp. Biochem. Physiol.,15, 313 (1965).

    Google Scholar 

  6. J. Banister and S. P. Mann, J. Physiol. (London),181, 13P (1965).

  7. L. Brouha, W. P. Cannon, and D. B. Dill, J. Physiol. (London),87, 345 (1936).

    Google Scholar 

  8. P. Duchêne-Marrulaz, J. Physiol. (Paris),66, 373 (1973).

    Google Scholar 

  9. B. Falck, J. Haggendal, and C. Owman, Q. J. Exp. Physiol.,48, 253 (1963).

    Google Scholar 

  10. C. B. Higgins, S. F. Vatner, and E. Braunwald, Pharmacol. Rev.,25, 119 (1973).

    Google Scholar 

  11. E. Musso and M. Vassalle, Cardiovasc. Res.,9, 490 (1975).

    Google Scholar 

  12. A. J. Pappano, J. Pharmacol. Exp. Ther.,180, 340 (1972).

    Google Scholar 

  13. R. I. Woods, Proc. Roy. Soc. London, B,176, 55 (1970).

    Google Scholar 

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Authors
  1. G. I. Bochkina
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  2. G. S. Sukhova
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  3. M. G. Udel'nov
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Bochkina, G.I., Sukhova, G.S. & Udel'nov, M.G. Effect of parasympathetic acceleration on bioelectrical activity of pacemaker cells of the desympathized and reserpinized frog heart. Bull Exp Biol Med 84, 1233–1236 (1977). https://doi.org/10.1007/BF00805869

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  • DOI: https://doi.org/10.1007/BF00805869

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