Abstract
DNA synthesis in different regions of regenerating skin is inhibited during chronic exposure to hypoxia. The decrease in the number of cells in the S-period of the mitotic cycle is evidence of inhibition of proliferation of the epithelial and connective-tissue cells, and this accounts for the longer time required for the healing of wounds in chronic oxygen deficiency.
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Literature Cited
A. M. Alekseeva, A. I. Klimakova, et al., Trudy Kalinin. Med. Inst., No. 11, 169 (1965).
A. A. Braun and I. Ya. Kamenetskii, Uchenye Zapiski Kabardino-Balkarsk. Univ. (Nal'chik), No. 33, 126 (1967).
L. G. Granov, Wound Healing at High Altitudes. Doctoral Dissertation, Khorog (1953).
G. A. Gribanov, Kosmich. Biol. i Med., No. 3, 71 (1972).
V. N. Dobrokhotov, in: Processes of Regeneration and Cell Multiplication in Animals [in Russian], Moscow (1961), p. 149.
S. S. Lugachev and M. T. Gololobova, Byull. Éksperim. Biol. i Med., No. 11, 93 (1973).
V. I. Lotova, in: Young Scientists in the Service of the Economy of the Upper Volga [in Russian], Kalanin (1973), p. 170.
F. Z. Meerson, L. F. Panchenko, et al., Kardiologiya, No. 7, 71 (1970).
T. G. Chernova, Uchenye Zapiski Kabardino-Balkarsk. Univ. (Nal'chik), No. 33, 122 (1966).
N. D. Yakovleva, Regeneration in the Skin after Exposure to Radiation and Hormonal Action (Autoradiographic and Histochemical Characteristics). Author's Abstract of Candidate's Dissertation, Obnisk (1969).
G. Aschan, Acta Soc. Med. Upsalien.,58, 265 (1953).
S. Britton and R. Kline, Am. J. Physiol.,145, 190 (1948).
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Khomullo, G.V., Lotova, V.I. Proliferative activity of regenerating skin in chronic hypoxia. Bull Exp Biol Med 79, 64–67 (1975). https://doi.org/10.1007/BF00805508
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DOI: https://doi.org/10.1007/BF00805508