Abstract
Polysaccharide complexes obtained by Westphal's method in the modification of L. A. Zil'ber et al. from tissues of the primary tumor node and distant metastases (lungs) of a chorionepithelioma of the uterus were used for the differential diagnosis between chorionepithelioma and hydatidiform mole. The reaction to intradermal injection of polysaccharide complexes obtained from distant metastases (lungs) of the uterine chorionepithelioma possess high specificity and sensitivity: a positive reaction developed only in patients with chorionepithelioma of the uterus and it was negative in patients with hydatidiform mole. During a marked decrease in size of the metastases in the lungs in the course of chemotherapy, when the immunologic reaction for chorionic gonadotropin fell to 300−100 i.u./liter urine, the reaction to intradermal injection of the polysaccharide complexes from the metastases of the uterine chorionepithelioma still remained positive.
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Laboratory of Experimental Endocrinology, Department of Gynecology, Institute of Experimental and Clinical Oncology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 79, No. 1, pp. 60–63, January, 1975.
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Dien, L.V., Savinskaya, A.P. & Novikova, L.A. Differential diagnosis of chorionepithelioma of the uterus and hydatidiform mole by an immunologic test. Bull Exp Biol Med 79, 60–63 (1975). https://doi.org/10.1007/BF00805507
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DOI: https://doi.org/10.1007/BF00805507