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Protective effect of serotonin against the inhibitory action of chlorpromazine on membrane potential of two-blastomere mouse embryos in vitro

  • Pharmacology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The depolarizing effect of chlorpromazine (in a concentration of 1·10−5–2·10−5 g/ml nutrient medium) on the membrane potential of mouse embryonic cells (at the two-blastomere stage) and also the effect of serotonin and prostaglandin F2α in concentrations of 1·10−4 and 4·10−6–8·10−6 g/ml, respectively, on this depolarization were investigated. Preliminary administration of serotonin reduced the depolarizing effect of chlorpromazine, but prostaglandin had no such action.

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Authors and Affiliations

  1. Academy of Medical Sciences of the USSR, USSR

    L. S. Persianinov

Authors
  1. B. V. Leonov
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  2. A. V. Limantsev
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  3. L. S. Persianinov
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Additional information

All-Union Scientific-Research Institute of Obstetrics and Gynecology, Ministry of Health of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 79, No. 1, pp. 41–43, January, 1975.

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Leonov, B.V., Limantsev, A.V. & Persianinov, L.S. Protective effect of serotonin against the inhibitory action of chlorpromazine on membrane potential of two-blastomere mouse embryos in vitro. Bull Exp Biol Med 79, 41–42 (1975). https://doi.org/10.1007/BF00805501

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  • DOI: https://doi.org/10.1007/BF00805501

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