Abstract
Adaptation to hypoxia for three months causes qualitative changes as well as a quantitative increase in the erythropoietic function of the bone marrow. This is shown by: a gradual increase in the proliferative activity of all cells of the erythroid series, including young forms (basophilic normoblasts and erythroblasts); an increase in the intensity of DNA synthesis; a decrease in the maturation time of the reticulocytes and the mean life span of the erythrocytes in the peripheral blood. The whole life cycle of the erythrocytes is apparently speeded up from the time of their appearance in the bone marrow to their death in the peripheral blood.
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Tavrovskaya, T.V., Tarakanova, O.I. & Barbashova, Z.I. Qualitative changes in parameters of erythropoiesis in man and animals adapted to prolonged hypoxia. Bull Exp Biol Med 79, 17–19 (1975). https://doi.org/10.1007/BF00805493
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DOI: https://doi.org/10.1007/BF00805493