Distribution ofβ-phenyl-γ-aminobutyric acid (phenygam) in the organism and cartain indices of its central effects
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A study was made on the distribution ofβ-phenyl-γ-aminobutyric acid (phenygam) in the rabbit organs and tissues.
Phenygam was determined by the method of electrophoretic division (sensitivity of method 4 mg %). A quatter of an hour after intravenous injection in a 100 mg/kg dose, phenygam is found in considerable amounts in the liver, kidneys, and urine, and as traces—in the blood and brain. In the liver, phenygam is subject to conversion rather than enzymatic disintegration, which was proved by experiments in vitro. Phenygam fails to influence the GABA level in the brain. Although phenygam penetrates from the blood into the brain only slightly, the amounts of it which gain access to the central nervous system are still large enough to cause changes in the behavior of animals. In the EEG this is manifested by a marked slow-down in the rhythm and an increase in the range of potentials taken from the frontal and the sincipito-occipital region. The myotatic reflex is little changed under the influence of phenygam. The latter is capable of a distinct hyperglycemic effect which is apparently due to its influence on the carbohydrate metabolism centers.
KeywordsPublic Health Nervous System Central Nervous System Carbohydrate Intravenous Injection
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