Abstract
The effect of duration of the interval (4–96 h) between irradiation of F1 (CBA×C57BL/6) hybrids and transplatation of bone marrow from C57BL/6 mice on manifestation of allogeneic inhibition of the stem cells was studied. In this particular donor-recipient model the degree of allogeneic inhibition was 90%. Transplantation of bone marrow carried out 4–48 h after irradiation had no effect on the number of colonies in the spleen of the F1 hybrids. Considerable abolition of allogeneic inhibition (33%) was observed if the parental cells were injected 96 h after irradiation. Remote transplantation had no effect on the number of colonies in the spleen of syngeneic recipients.
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Golovistikov, I.N. Importance of the time of bone marrow transplantation for manifestation of allogeneic inhibition of stem cells. Bull Exp Biol Med 81, 413–415 (1976). https://doi.org/10.1007/BF00804935
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DOI: https://doi.org/10.1007/BF00804935