Bulletin of Experimental Biology and Medicine

, Volume 81, Issue 3, pp 382–385 | Cite as

Syngeneity as a factor in cooperation between T- and B-lymphocytes

  • L. N. Fontalin
  • T. K. Novikova
  • L. A. Pevnitskii
  • I. A. Kondrat'eva
Microbiology and Immunology
  • 13 Downloads

Abstract

Effectiveness of cooperation between (CBA x C57BL/6)F1 thymocytes and CBA bone-marrow cells in the immune response to sheep's red cells was compared with syngeneic combinations of the same cells in culturein vivo. The selectiveness of cooperation between T- and B-lymphocytes of different origin also was investigated in incomplete (CBA x C57BL/6)F1→CBA chimeras obtained with the aid of cyclophosphamide, in which the donors were primed with sheep's red cells and the recipients were either intact or were tolerant to that antigen. F1 T-cells were shown to cooperate with CBA B-cells 10–50 times less effectively than with syngeneic B-cells. It is postulated that the similar antigenic structure of the cell membrane of T- and B-lymphocytes, acting in conjunction with their physical contact, increases the effectiveness of action of the T-mediator on the B-cell

Key Words

T- and B-lymphocytes intercellular interaction genetic compatibility chimerism 

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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • L. N. Fontalin
  • T. K. Novikova
  • L. A. Pevnitskii
  • I. A. Kondrat'eva

There are no affiliations available

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