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Bulletin of Experimental Biology and Medicine

, Volume 81, Issue 3, pp 379–381 | Cite as

Effect of Parmidine (pyridinolcarbamate) on platelet aggregation, blood coagulation, and fibrinolysis

  • M. D. Mashkovskii
  • K. M. Lakin
  • M. S. Ovnatanova
  • G. Ya. Shvarts
Pharmacology

Abstract

The effect of Parmidine (pyridinolcarbamate) on platelet aggregation, blood coagulation, and fibrinolysis was studied in rabbits. After direct addition of Parmidine to platelet-enriched plasma aggregation of the platelets produced by serotonin (5-HT) and adrenalin was reduced. After oral administration of Parmidine to animals, aggregation induced by ADP, 5-HT, and adrenalin was inhibited, blood coagulation was reduced, and fibrinolysis was accelerated.

Key Words

Parmidine (Anginin, pyridinolcarbamate) platelets fibrinolysis 

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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • M. D. Mashkovskii
    • 1
  • K. M. Lakin
  • M. S. Ovnatanova
  • G. Ya. Shvarts
  1. 1.Academy of Medical Sciences of the USSRUSSR

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