Abstract
The effect of droperidol, a butyrophenone derivative, on the food reflex to electrical stimulation of the hypothalamic food center was studied in experiments on freely moving rabbits. Intravenous injection of droperidol (0.3 mg/kg) lowered the threshold of the evoked food response. Inhibitory influences of the anterior neocortical zones on food responses were absent but facilitatory influences of the caudal regions of the cortex were preserved or even somewhat increased. The effects observed can be explained by the dopamine-negative action of droperidol and by disturbance of the brain inhibitory system.
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Zilov, V.G., Rogacheva, S.K. Effect of droperidol on corticofugal influences in food motivation reflexes. Bull Exp Biol Med 81, 299–302 (1976). https://doi.org/10.1007/BF00804900
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DOI: https://doi.org/10.1007/BF00804900