Abstract
Responses of the mesenteric microvessels of rats to application and intravenous injection of bradykinin were studied in acute experiments using intravital microscopy. No clear bioelectric response of the smooth-muscle cells of the microvessels to local application of bradykinin could be found in electrophysiological experiments. In another series of experiments the dynamics of vasomotor activity were studied after the same treatment by the split-image method. The response of the microvessels to bradykinin application was shown to vary in character depending principally on whether the preparation was being applied for the first or subsequent time. It is suggested that bradykinin acts on the mesenteric microvessels through the intermediary of other vasoactive substances.
Similar content being viewed by others
Literature Cited
P. N. Aleksandrov and A. M. Chernukh, Pat. Fiziol., No. 1, 83 (1972).
P. Ya. Gaponyuk and V. I. Oivin, Byull. Éksperim. Biol. i Med., No. 6, 23 (1971).
E. V. Montsevichyute-Éringene, Pat. Fiziol., No. 4, 71 (1964).
M. I. Timkina, in: Microcirculation, Function, Structure (Proceedings of the First All-Union Conference [in Russian], Moscow (1972), p. 137.
M. I. Timkina and A. M. Chernukh, Byull. Éksperim. Biol. i Med., No. 11, 8 (1971).
D. Armstrong, R. M. L. Dry, C. A. Keele, et al., J. Physiol. (London),120, 326 (1953).
C. C. Chou, E. D. Frohlich, and E. C. Texter, J. Physiol. (London),176, 1 (1965).
N. P. De Pasquale and G. E. Burch, Am. Heart J.,75, 630 (1968).
T. E. Emerson, Am. J. Physiol.,212, 1455 (1967).
S. M. Hilton, Physiol. Rev.,42, Suppl. 5, 455 (1962).
C. Hyman and R. L. Paldino, Bibl. Anat. (Basel),9, 38 (1967).
H. A. Kontes, W. Shapiro, J. H. Magel, et al., Circulat. Res.,14, 351 (1964).
J. Nakano, Arch. Internat. Pharmacodyn.,157, 1 (1965).
B. J. Northover, J. Path.,98, 265 (1969).
M. C. Starr and G. B. West, J. Pharm. Pharmacol.,18, 838 (1966).
R. Weiner, Bibl. Anat. (Basel),9, 17 (1967).
Author information
Authors and Affiliations
Additional information
Laboratory of General Pathology and Experimental Therapy, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 3, pp. 259–261, March, 1976.
Rights and permissions
About this article
Cite this article
Chernukh, A.M., Aleksandrov, P.N. & Timkina, M.I. Action of bradykinin on the mesenteric microcirculation in rats. Bull Exp Biol Med 81, 289–291 (1976). https://doi.org/10.1007/BF00804897
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00804897