Abstract
Peroral administration of dimethylamine, sodium nitrite, and a combination of these two precursors of endogenously synthesized dimethylnitrosamine to rats increases the activity of the demethylase of this carcinogen in the liver microsomes. Under chronic experimental conditions the addition of dimethylamine to the rats' diet stimulates demethylase activity even if the diet contains casein, an inducer of this enzyme system. Actinomycin D, an inhibitor of protein synthesis, prevents the increase in demethylase activity in the microsomal fraction induced by dimethylamine.
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Karpilovskaya, E.D., Rubenchik, B.L. Effect of precursors of endogenously synthesized carcinogen dimethylnitrosamine on activity of its demethylase in rat liver. Bull Exp Biol Med 84, 1759–1761 (1977). https://doi.org/10.1007/BF00804829
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DOI: https://doi.org/10.1007/BF00804829