Abstract
The sera of rabbits immunized by fractions containing nontype-specific group A streptococcal antigens, belonging to cell wall proteins, were studied by the indirect immunofluorescence method. Antibodies reacting with fibroblasts of the interstitial connective tissue of the human heart were found in the sera. On the basis of the results of absorption experiments it is postulated that a cross-reacting antigen common with an antigen of the fibroblasts is present in some hydrochloric acid extracts obtained from streptococci of groups A and C.
Similar content being viewed by others
Literature Cited
V. V. Akimova, S. G. Shuratova, V. P. Bukhova, et al., Zh. Mikrobiol., No. 2, 27 (1977).
N. A. Borodiyuk, I. I. Rassokhina, T. A. Danilova, et al., Byull. Éksp. Biol. Med., No. 4, 443 (1976).
I. M. Lyampert, O. I. Vvedenskaya, and T. A. Danilova, Immunology,11, 313 (1966).
I. M. Lyampert and T. A. Danilova, Prog. Allergy,18, 423 (1975).
I. M. Lyampert, L. V. Beletskaya, N. A. Borodiyuk, et al., Immunology,31, 47 (1976).
G. A. Ugryumova and N. A. Borodiyuk, Byull. Éksp. Biol. Med., No. 4, 70 (1973).
S. G. Shuratova, V. V. Akimova, and V. P. Bukhova, Zh. Mikrobiol., No. 7, 11 (1974).
E. N. Freimer, J. Exp. Med.,117 377 (1963).
R. B. Goudie, C. Horne, et al., Lancet,2, 1224 (1966).
M. N. Kaplan and F. T. Rapaport, in: Progressin Immunology (1st International Congress of Immunology, ed. by B. Amos), Academic Press, New York (1971), p. 1153.
D. Kingston and L. E. Glynn, Immunology,21, 1003 (1971).
R. M. Krause, in: Methods in Immunology and Immunochemistry (ed. by C. A. Williams), Vol. 1, Academic Press, New York, 1967, p. 34.
G. Kronvall, J. Immunol.,111 1401 (1973).
C. K. Osterland, E. J. Miller, W. W. Karakawa, et al., J. Exp. Med.,123, 599 (1966).
M. R. Salton and R. W. Horne, Biochim. Biophys. Acta,7, 177 (1951).
Rights and permissions
About this article
Cite this article
Ugryumova, G.A., Lyampert, I.M., Kolesnikova, V.Y. et al. Reaction of antibodies to antigens of group A streptococcus with fibroblasts of interstitial connective tissue of the human heart. Bull Exp Biol Med 84, 1722–1724 (1977). https://doi.org/10.1007/BF00804817
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00804817