Changes in activity of some mechanisms of specific and nonspecific immunity in vitamin B1 deficiency

  • A. D. Pletsityi
Microbiology and Immunology


The effect of thiamine deficiency on the immune response and activity of certain mechanisms of natural immunity was studied in adult rats. Thiamine deficiency was simulated experimentally by a single injection of hydroxythiamine, a vitamin B1 antagonist. Administration of hydroxythiamine caused a marked decrease in complement activity, phagocytic activity of the peripheral blood leukocytes, bactericidal activity of the serum, and antibody production in response to immunization with sheep's red blood cells. Conversely, lysozyme activity increased. In vitamin B1 deficiency the intensity of incorporation of [14C]leucine into liver protein synthesis was reduced.

Key Words

thiamine deficiency hydroxythiamine factors of natural immunity immune response 


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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • A. D. Pletsityi

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