Differences between dose-effect curves for ethanol in mice of different lines for locomotion and standing
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The dose-effect curve of ethanol (1–5 g/kg, perorally) based on the study of locomotion in four male mice of four different lines (SHR, BALB/c C3HA, C57BL/6) is characterized by a gradual rise to a peak (at 3 g/kg for all lines except C3HA, for which it is 5 g/kg) and a subsequent fall. The curve based on the study of standing erect is flat and falls steadily to zero. The excitatory effect of ethanol (1.5–3 g/kg) can therefore be measured as an increase in locomotion. The influence of different preparation (or other factors) on this effect must be assessed simultaneously with respect to locomotion and standing, for because of the change in direction of the curve a decrease in locomotion could indicate either weakening or strengthening of the excitatory action of ethanol. The parallel decrease in the frequency of standing indicates potentiation of the action of ethanol, whereas an increase in the frequency of standing indicates weakening of its action.
Key Wordsethanol dose-effect curves locomotion standing mice of various lines
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