Mechanisms of the primary response of the adrenal cortex to pain stress in dogs

  • S. A. Eremina
  • T. V. Kondrukh
  • R. F. Morozova
  • E. A. Rogacheva
Pathological Physiology and General Pathology
  • 12 Downloads

Abstract

A sharp decrease in the glucocorticoid content accompanied by an increase in the free cholesterol and a decrease in the content of esterified cholesterol were observed in the adrenal cortex of dogs 10–15 sec after nociceptive stimulation. The blood concentrations of the hormones were increased, mainly due to the proteinbound hydrocortisone fraction. The next phase of the response (30–60 sec after stimulation) was marked by activation of synthetic processes, leading to considerable accumulation of hormones in the gland. The blood glucocorticoid level was doubled, the original ratio of hydrocortisone to corticosterone was restored, and the transcortin depot was replenished. The role of the adrenal and transcortin deports of glucocorticoids in the feedback mechanism during stress is discussed.

Key Words

stress adrenal cortex glucocorticoids 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    T. I. Ivanenko, N. R. Shchedrina, and M. I. Kondor, Probl. Éndokrinol., No. 1, 72 (1968).Google Scholar
  2. 2.
    M. A. Krekhova and M. K. Chekhranova, Vopr. Med. Khim., No. 1, 93 (1971).Google Scholar
  3. 3.
    L. N. Negrei and E. B. Sopotsinskaya, Lab. Delo, No. 1, 15 (1975).Google Scholar
  4. 4.
    G. Franksson and C. A. Gemzell, Acta Chir. Scand.,106, 24 (1953).Google Scholar
  5. 5.
    A. A. Dandberg, D. M. Neilson, J. Plamer, et al., J. Clin. Endocrinol.,13, 629 (1953).Google Scholar
  6. 6.
    G. Sayers and M. Sayers, Endocrinology,40, 265 (1947).Google Scholar

Copyright information

© Plenuym Publishing Corporation 1979

Authors and Affiliations

  • S. A. Eremina
  • T. V. Kondrukh
  • R. F. Morozova
  • E. A. Rogacheva

There are no affiliations available

Personalised recommendations