Abstract
A luminescence microscopic study of a short-term culture of human lymphocytes with the aid of acridine orange showed that the modified state of the interphase chromatin in patients with Down's syndrome can be partly restored to normal by incubating the patient's lymphocytes with healthy human serum. These results suggest that the component inhibiting chromatin activation is absent or qualitatively changed in the serum of patients with Down's syndrome. The incomplete restoration of the ability of the chromatin to fix the dye points to irreversible changes in the structure of the chromatin itself, in the direction of condensation.
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Fedorova, K.N., Inshakova, V.M. & Spitkovskii, D.M. Effect of autologous serum on the state of the interphase chromatin of the lymphocytes in Down's syndrome. Bull Exp Biol Med 78, 1191–1193 (1974). https://doi.org/10.1007/BF00804635
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DOI: https://doi.org/10.1007/BF00804635