Bulletin of Experimental Biology and Medicine

, Volume 87, Issue 4, pp 290–292 | Cite as

Genesis of amnesias induced by electroconvulsive shock

  • R. I. Kruglikov
  • L. G. Polyanskaya
Pathological Physiology and General Pathology
  • 12 Downloads

Abstract

The effect of a series of repeated electric shocks (ES) on preservation of conditioned reflexes and on the concentration of free amino acids (AA) in the rat brain was studied. Under the influence of repeated ES, the first of which was applied 24 h after irradiation, the rats developed amnesia. The excitatory AA concentration in the brain was unchanged, but the concentrations of inhibitory AA and also of phenylalanine and tyrosine fell sharply. The AA concentration in the blood plasma rose. It is suggested that the onset of amnesia was due to a change in the balance between excitatory and inhibitory AA in favor of the former. A definite role in the genesis of these disturbances may be played by changes in the functional state of the blood-brain barrier.

Key Words

amnesia free amino acids in the brain blood-brain barrier 

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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • R. I. Kruglikov
  • L. G. Polyanskaya

There are no affiliations available

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