Abstract
Acute pancreatitis developed 15 min after injection of 0.65 mg active elastase into the pancreatic duct. The histological changes in the gland tissue increased from the edematous form to necrotic pancreatitis with a hemorrhagic component, and with an increase in the dose of elastase injected up to 2.6 mg the elastic structures of the blood vessels were destroyed. The changes described above were accompanied by a decrease in the proelastase content in the pancreatic tissue and a decrease in the inhibitory power of the blood serum. The results are evidence of the important role of elastase in the pathogenesis of acute pancreatitis.
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Chernoyarova, O.D., Podol'skii, A.E. Mechanism of action of active elastase on pancreatic tissue. Bull Exp Biol Med 78, 1340–1342 (1974). https://doi.org/10.1007/BF00804378
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DOI: https://doi.org/10.1007/BF00804378