Effect of various doses of progesterone and estrogens on embryonic development in ovariectomized rats
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Experiments were carried out on pregnant noninbred rats. The animals were ovariectomized on the 8th day of pregnancy, continuation of which was ensured by injection of the principal ovarian hormones: estradiol dipropionate, folliculin, estriol, and progesterone in various combinations. The animals were killed on the 21st day of pregnancy, and the fetuses were removed and inspected externally. The results showed that ovariectomy, carried out on the 8th day of pregnancy, interrupted its course. Normal embryogenesis took place only after injection of all the principal ovarian hormones.
Key wordspregnancy embryogenesis ovariectomy progesterone estrogens
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