Abstract
Definite changes in the mitotic index (MI) of bone marrow cells of Wistar rats were discovered during the 24-h period. The curve showing changes in the number of mitoses of the granulopoietic cells is bimodal in character (maxima at 9 a. m. and 8 p. m.), while that for the erythropoietic cells is unimodal (maximum at 9 a. m.). Correlation is observed between changes in MI and the labeling index (incorporation of thymidine-H3) of individual bone marrow cells. The diurnal fluctuations in proliferative activity of the bone marrow cells are accompanied by corresponding changes in the total number of myelokaryocytes.
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Literature Cited
I. A. Alov, Tsitologiya, No. 3, 297 (1962).
M. T. Gololobova, in: Regeneration and Cell Division [in Russian], Moscow (1968), p. 79.
G. P. Gruzdev, M. M. Rozhdestvenskii, M. I. Fedotova, et al., Byull. Éksperim. Biol. i Med., No. 2, 83 (1966).
V. N. Dobrokhotov and R. I. Nikonorova, Byull. Éksperim. Biol. i Med., No. 9, 91 (1962).
L. P. Kosichenko, Byull. Éksperim. Biol. i Med., No. 6, 98 (1960).
N. V. Krasil'nikova, Byull. Éksperim. Biol. i Med., No. 4, 100 (1962).
S. G. Mamontov, Byull. Éksperim. Biol. i Med., No. 11, 103 (1968).
S. G. Mamontov, Byull. Éksperim. Biol. i Med., No. 10, 85 (1969).
I. V. Markelova, Tsitologiya, No. 3, 318 (1967).
Yu. A. Romanov and R. A. Gibadullin, Byull. Éksperim. Biol. i Med., No. 2, 98 (1967).
L. E. Sil'vestrova, Byull. Éksperim. Biol. i Med., No. 1, 87 (1972).
A. M. Mauer, Blood,26, 1 (1965).
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Uryadnitskaya, T.I. Diurnal fluctuations in proliferative activity of rat bone marrow cells. Bull Exp Biol Med 78, 1323–1325 (1974). https://doi.org/10.1007/BF00804373
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DOI: https://doi.org/10.1007/BF00804373