Abstract
A decrease in the number of lymphocytes capable of responding to phytohemagglutinin (PHA) and in mixed culture was found in thymus-deficient dogs (thymectomized followed by lethal irradiation and transplantation of autologous bone marrow). On the basis of these results and the increase in the time before rejection of skin allografts in these animals, established previously, it was concluded that dogs have a population of lymphocytes of thymic origin that participate in the responses of cellular immunity and blast transformation under the influence of PHA.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
M. N. Novikova, A. G. Fedotenkov, and I. L. Chertkov, Probl. Gematol., No. 2, 16 (1968).
N. L. Samoilina, G. A. Udalov, and I. L. Chertkov, in: Proceedings of a Symposium on the Conservation, Cultivation, and Typing of Bone Marrow [in Russian], Moscow (1971), p. 120.
J. L. Chertkov, G. V. Sukyasyan, M. N. Novikova, et al., Radiat. Res.,46, 129 (1971).
W. A. Kisken, Nature,224, 76 (1969).
R. T. Smith, Nature,11, 178 (1972).
Rights and permissions
About this article
Cite this article
Gurevich, O.A., Udalov, G.A. Thymus-dependent differentiation of lymphocytes in dogs assessed by tests for allogeneic lymphocytes and phytohemagglutinin. Bull Exp Biol Med 78, 1299–1301 (1974). https://doi.org/10.1007/BF00804365
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00804365