Bulletin of Experimental Biology and Medicine

, Volume 78, Issue 5, pp 1296–1298 | Cite as

Passive transmission of experimental allergic encephalomyelitis by serum antibrain antibodies

  • G. A. Vilkov
  • L. I. Mezhova
Microbiology and Immunology


Intravenous injection of γ-globulin obtained from the serum of dogs in the preclinical period of experimental allergic encephalomyelitis into guinea pigs, followed by thermal coagulation of an area of the brain, leads to the development of fibrinoid necrosis of the vascular walls, perivascular and diffuse infiltration of a large zone of brain around the focus of necrosis, and demyelination. These changes develop 24 h after coagulation. γ-Globulin from intact dogs and from a dog with symptoms of encephalomyelitis did not cause the development of an inflammatory reaction.

Key Words

experimental allergic encephalomyelitis antibrain antibodies 


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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • G. A. Vilkov
  • L. I. Mezhova

There are no affiliations available

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