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Antioxidant action of steroid hormones on the peroxidation of mitochondrial membrane lipids in vivo and in vitro

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The action of several steroids on lipid peroxidation in the mitochondrial membranes of the rat liver in the presence of Fe++ ions was studied by recording the very weak chemiluminescence. All the hormones investigated had an antioxidant action, but the mechanism of this action varied. Removal of the ovaries and adrenals gave effects opposite to those of injection of estrogens and glucocorticoids in vitro.

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Literature Cited

  1. Yu. A. Vladimirov, P. V. Sergeev, R. D. Seifulla, et al., Molekul. Biol., No. 7, 247 (1973).

    Google Scholar 

  2. Yu. A. Vladimirov and A. I. Archakov, Peroxidation of Lipids in Biological Membranes [in Russian], Moscow (1972).

  3. Yu. A. Vladimirov, T. B. Suslova, and V. I. Olenev, Biofizika,14, 836 (1969).

    Google Scholar 

  4. Yu. A. Vladimirov, T. B. Suslova, V. I. Olenev, et al., in: Mitochondria. Biochemical Functions in the System of Cell Organelles [in Russian], Moscow (1969), p. 203.

  5. E. A. Korepanova, K. I. Trukhmanova, V. F. Antonov, et al., in: Biophysics of Membranes. Proceedings of a Symposium [in Russian], Kaunas (1971), p. 476.

  6. E. A. Neifakh and V. E. Kagan, Biokhimiya,34, 511 (1969).

    Google Scholar 

  7. P. V. Sergeev, R. D. Seifulla, and A. I. Maiskii, Molecular Aspects of the Action of Steroid Hormones [in Russian], Moscow (1971).

  8. A. S. Allison, in: Society for Endocrinology (Great Britain). Cell Mechanisms in Hormone Production and Action. Proceedings of a Symposium, London (1961), p. 42.

  9. F. E. Hunter, Jr., J. M. Gebicki, P. E. Hoffsten, et al., J. Biol. Chem.,238, 828 (1963).

    Google Scholar 

  10. P. Karlson, Dtsch. med. Wschr.,86, 668 (1961).

    Google Scholar 

  11. P. Talalay, in: Biological Approaches to Cancer Chemotherapy, London (1961), p. 59.

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Authors
  1. V. M. Gukasov
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  2. P. V. Sergeev
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  3. R. D. Seifulla
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  4. Yu. A. Vladimirov
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Gukasov, V.M., Sergeev, P.V., Seifulla, R.D. et al. Antioxidant action of steroid hormones on the peroxidation of mitochondrial membrane lipids in vivo and in vitro. Bull Exp Biol Med 78, 1274–1276 (1974). https://doi.org/10.1007/BF00804356

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  • DOI: https://doi.org/10.1007/BF00804356

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