Functional state of the liver in experimental staphylococcal infection
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In infection produced by intravenous injection of staphylococci of strain Wood-46 into albino rats, marked changes take place in the liver function and, in particular, the synthesis and liberation of bile acids are sharply inhibited. Their total concentration in the bile falls chiefly on account of taurocholic, glycocholic, and deoxycholic acids, whereas the concentration of cholic acid itself rises, evidently because of inhibition of the conversion of cholesterol into primary bile acids and conjugation of cholic acid with glycine and taurine. The hyperbilirubinocholia observed in the early periods of infection arises on account of hemolysis of the red cells.
Key wordsstaphylococcal toxin rat liver bile acids cholesterol
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