Abstract
2,4-Dinitrophenol (DNF) (5×10−4 M), oligomycin (10 μg/ml), rotenone (10−5 M), cyanide (10−3 M), and azide (2×10−3 M), inhibitors of energy metabolism, completely suppress the synthesis of mitochondrial RNA in whole cells of an ascites tumor of the rat ovary. In a system in vitro oligomycin and rotenone had no effect on RNA synthesis in the mitochondria, whereas DNP, cyanide, and azide inhibited it only 15 min after their addition to the incubation medium.
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Blednov, Y.A., Panchenko, L.F. & Shuppe, N.G. Effect of energy inhibitors on the synthesis of mitochondrial RNA. Bull Exp Biol Med 78, 1262–1264 (1974). https://doi.org/10.1007/BF00804352
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DOI: https://doi.org/10.1007/BF00804352