Bulletin of Experimental Biology and Medicine

, Volume 78, Issue 5, pp 1248–1250 | Cite as

Changes in the tissue blood flow in the rabbit brain after burn, acute radiation, and combined injuries

  • G. A. Bykov
  • M. Yu. Sternin
  • M. D. Malamud
Pathological Physiology and General Pathology
  • 10 Downloads

Abstract

The tissue blood flow of the brain was determined in experiments on rabbits with the aid of xenon-133 after severe burns affecting 20% of the body surface, whole-body x-ray irradiation in a dose of 900 rad, and combined exposure to both factors. The cerebral blood flow was found to be reduced by a lesser degree in burns than the minute volume of the heart (on the average by 20–30% and 50%, respectively). In combined trauma the decrease in the cerebral blood flow was the same as with isolated burns or radiation injury. The authors suggest that a greater decrease in the cerebral blood flow is incompatible with life. The results are evidence of the existence of compensatory mechanisms aimed at maintaining the cerebral blood flow despite a fall in the minute volume of the heart.

Key Words

brain tissue blood flow burns and combined radiation and burn injury 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    P. V. Voloshin, in: Proceedings of a Symposium on the Diagnosis and Treatment of Burn Shock [in Russian], Khar'kov (1969), p. 33.Google Scholar
  2. 2.
    V. P. Lapshin, in: Proceedings of a Symposium on the Diagnosis and Treatment of Burn Shock [in Russian], Khar'kov (1969).Google Scholar
  3. 3.
    G. D. Leshchenko and P. V. Voloshin, in: Proceedings of a Symposium on the Diagnosis and Treatment of Burn Shock [in Russian], Khar'kov (1969).Google Scholar
  4. 4.
    N. N. Livshits, Z. I. Apanasenko, V. Ya. Klimovitskii, et al., Uspekhi Sovr. Biol.,67, No. 2, 261 (1969).Google Scholar
  5. 5.
    R. M. Lyubimova-Gerasimova, Radiobiologiya,21, No. 1, 82 (1962).Google Scholar
  6. 6.
    L. L. Stazhadze, M. V. Vasmanova, and B. V. Chetvertushkin, in: The Reaction in Clinical Emergency Surgery and Traumatology [in Russian], Moscow (1970), p. 90.Google Scholar
  7. 7.
    S. S. Kety, in: Neurochemistry, Springfield (1955), p. 294.Google Scholar
  8. 8.
    S. S. Kety, Pharmacol. Rev.,3, 1 (1951).Google Scholar
  9. 9.
    N. Veall and B. Z. Mallet, Phys. Med. Biol.,10, 375 (1965).Google Scholar
  10. 10.
    K. L. Zierler, Circulat. Res.,16, 309 (1965).Google Scholar
  11. 11.
    M. D. Hoedt-Rasmussen, E. Sveinsdottir, et al., Circulat. Res.,18, 237 (1966).Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • G. A. Bykov
  • M. Yu. Sternin
  • M. D. Malamud

There are no affiliations available

Personalised recommendations