Bulletin of Experimental Biology and Medicine

, Volume 78, Issue 5, pp 1238–1240 | Cite as

Effect of adrenergic β-receptor block on early responses of the hematopoietic organs to stress

  • P. D. Gorizontov
  • O. I. Belousova
  • Yu. I. Zimin
Pathological Physiology and General Pathology


Changes in the cell composition of the hematopoietic organs of rats in response to injection of adrenalin were investigated after blocking of the adrenergic β-receptors with propranolol. After the injection of adrenalin the number of lymphocytes in the spleen fell but the number in the bone marrow rose, and at the same time the number of mature neutrophils decreased. Preliminary injection of the β-adrenergic blocking agent considerably reduced migration of the lymphocytes into the bone marrow but did not affect the intensity of cellular depopulation of the spleen. It is concluded that β-adrenergic mechanisms play an important role in the early response of the bone marrow to extremal factors.

Key Words

stress response hematopoiesis adrenergic block 


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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • P. D. Gorizontov
    • 1
  • O. I. Belousova
  • Yu. I. Zimin
  1. 1.Academy of Medical Sciences of the USSRUSSR

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