Bulletin of Experimental Biology and Medicine

, Volume 79, Issue 3, pp 305–308 | Cite as

A study of interaction between lymphocytes and tumor cells with the scanning electron microscope

  • Yu. A. Umanskii
  • T. P. Evgen'eva
  • R. A. Semenova-Kobzar'
  • L. Ya. Kushko


It was shown with the aid of the scanning electron microscope that in the course of interaction between lymphocytes of BALB/c mice with methylcholanthrene-induced sarcoma and autologous tumor cells the state of the surface membranes of the cells underwent substantial changes. Lymphocytes separated from autologous tumor cells by means of a Millipore filter impermeable to the cells formed long cytoplasmic processes which passed through the pores of the filter and established close contact with the tumor cells. Under these conditions the tumor cells became spherical in shape, they swelled, and “holes” appeared in the surface membrane, leading to lysis of the cell.

Key Words

lymphocytes tumor cells cytoplasmic processes 


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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • Yu. A. Umanskii
  • T. P. Evgen'eva
  • R. A. Semenova-Kobzar'
  • L. Ya. Kushko

There are no affiliations available

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