Bulletin of Experimental Biology and Medicine

, Volume 79, Issue 3, pp 262–264 | Cite as

Formation of a stable DNA-protein bond by the action of a bifunctional alkylating mutagen (embichin-HN2) on chromatin

  • N. A. Sokolov
  • E. G. Piker
  • M. S. Zakaryan
  • G. G. Blinova
  • P. I. Tseitlin
Biochemistry and Biophysics
  • 16 Downloads

Abstract

By the use of various methods of deproteinization of chromatin (gel-filtration, ultracentrifugation, chromatography on calcium hydroxyapatite) the authors showed that by interaction between the chromatin and a bifunctional alkylating agent (embichin-HN2) a DNA-protein complex is formed.

Key Words

thymus chromatin DNA and its bond with protein alkylating mutagens (embichin) 

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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • N. A. Sokolov
  • E. G. Piker
  • M. S. Zakaryan
  • G. G. Blinova
  • P. I. Tseitlin

There are no affiliations available

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