Bulletin of Experimental Biology and Medicine

, Volume 79, Issue 3, pp 255–258 | Cite as

Effect of frequency of action of a pathogenic factor on kidney tissue: Autoradiographic study

  • Yu. L. Kogan
Pathological Physiology and General Pathology


The kidney tissue of mice was investigated autoradiographically by means of thymidine-H3 under normal conditions and after single and repeated injections of mercuric chloride at intervals of 1 day and 1 week. Noninbred male albino mice (26) weighing 25–30 g were used in the experiments. In the control mice (5) the index of labeling in the epithelium of the prximal tubules was relatively higher. After the more frequent action of the pathogenic factor on the kidney, more cells synthesizing DNA appeared in it. It is postulated that the correlation existing between the number of labeled epithelial cells of the proximal tubules and the number of flattened cells lying beyond their basement membranes is a distinctive index of the regenerative changes in the tissue of the damaged kidney.

Key Words

regeneration frequency of injury kidney 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    N. F. Kan'shina, Arkh. Pat., No. 10, 3, (1970).Google Scholar
  2. 2.
    A. A. Pal'tsyn, B. V. Vtyurin, K. V. Botsmanov, et al., in: Biological Rhythms in Mechanisms of Compensation of Disturbed Functions [in Russian], Moscow (1973), p. 87.Google Scholar
  3. 3.
    D. S. Sarkisov, L. D. Krymskii, K. V. Botsmanov, et al., Arkh. Pat., No. 3, 22 (1969).Google Scholar
  4. 4.
    A. G. Ufimtseva, “Enzyme histochemistry of the nephron under normal and pathological conditions (mercuric chloride nephrosis, cytotoxic glomerulonephritis, nephrocalcinosis),” Author's Abstract of Candidate's Dissertation, Moscow (1971).Google Scholar
  5. 5.
    J. N. Bickers, E. H. Bresler, and R. Weinberger, J. Pharmacol. Exp. Ther.,128, 83 (1966).Google Scholar
  6. 6.
    F. E. Cuppage and A. Tate, Am. J. Path.,51, 465 (1967).Google Scholar
  7. 7.
    F. E. Cuppage and A. Tate, Path. Microbiol. (Basel),32, 327 (1968).Google Scholar
  8. 8.
    T. Okura et al., Jap. J. Clin. Med.,2, 147 (1972).Google Scholar
  9. 9.
    R. P. Wedeen, Prog. Nucl. Med.,2, 147 (1972).Google Scholar
  10. 10.
    M. J. Wachstein, J. Histochem.,3, 246 (1955).Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • Yu. L. Kogan

There are no affiliations available

Personalised recommendations