Effect of frequency of action of a pathogenic factor on kidney tissue: Autoradiographic study
The kidney tissue of mice was investigated autoradiographically by means of thymidine-H3 under normal conditions and after single and repeated injections of mercuric chloride at intervals of 1 day and 1 week. Noninbred male albino mice (26) weighing 25–30 g were used in the experiments. In the control mice (5) the index of labeling in the epithelium of the prximal tubules was relatively higher. After the more frequent action of the pathogenic factor on the kidney, more cells synthesizing DNA appeared in it. It is postulated that the correlation existing between the number of labeled epithelial cells of the proximal tubules and the number of flattened cells lying beyond their basement membranes is a distinctive index of the regenerative changes in the tissue of the damaged kidney.
Key Wordsregeneration frequency of injury kidney
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