Bulletin of Experimental Biology and Medicine

, Volume 78, Issue 2, pp 949–950 | Cite as

Biosynthesis of ubiquinone-9 in the regenerating albino rat liver

  • V. V. Fedurov
  • I. V. Kuz'menko
Morphology and Pathomorphology


The uptake of radioactivity from acetate-1-C14 into ubiquinone-9 in thin slices of regenerating albino rat liver was investigated on the 1st, 2nd, 3rd, 6th, 9th, 12th, and 15th day after partial hepatectomy. Marked acceleration of ubiquinone-9 biosynthesis was found during the first 3 days after removal of two-thirds of the liver. The maximal increase in biosynthesis (almost eightfold) was found 24 h after hepatectomy. This increase in the rate of ubiquinone-9 biosynthesis coincides with the time of increased mitotic activity and accelerated biogenesis of the mitochondria. A very small increase in the biosynthesis of ubiquinone-9 was found on the 12th and 15th days of regeneration.

Key Words

ubiquinone-9 hepatectomy regeneration of the liver 

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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • V. V. Fedurov
  • I. V. Kuz'menko

There are no affiliations available

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