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Bulletin of Experimental Biology and Medicine

, Volume 78, Issue 2, pp 943–945 | Cite as

Effect of thyrocalcitonin on the mineral component of regenerating bone during healing of fractures

  • V. A. Landa
  • A. I. Briskin
Experimental Biology
  • 14 Downloads

Abstract

Changes in the state of the mineral component of bone tissue (hydroxyapatite) during reparative regeneration of bone after administration of thyrocalcitonin (TCT) were studied in experiments on rabbits. Methods of histology, quantitative microroentgenography, and x-ray diffraction were used. TCT has no marked stimulant effect on normal osteogenesis and mineralization of newly formed bone tissue. However, mineralization of the callus follows an optimal course and osteoporosis of the fragments is much less marked than in animals not receiving TCT.

Key Words

regeneration of bone thyrocalcitonin mineralization of bone tissue hydroxyapatite 

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Literature Cited

  1. 1.
    A. I. Briskin, L. I. Stekol'nikov, D. D. Sumarokov, et al., Dokl. Akad. Nauk SSSR,196, 227 (1971).Google Scholar
  2. 2.
    V. A. Landa, Mineralization of Bone Tissue during Primary and Secondary Healing of Fractures, Candidate's Dissertation, Moscow (1970).Google Scholar
  3. 3.
    Yu. M. Lopukhin, V. P. Okhotskii, V. N. Savvin, et al., Vestn. Akad. Med. Nauk SSSR, No. 1, 63 (1968).Google Scholar
  4. 4.
    Yu. M. Lopukhin, V. P. Okhotskii, and V. N. Savvin, in: Proceedings of the 2nd Congress of Traumatologists and Orthopedic Surgeons of the USSR [in Russian], Moscow (1969), p. 86.Google Scholar
  5. 5.
    V. P. Okhotskii, The Healing of Closed Diaphyseal Fractures under Different Conditions of Osteosynthesis. Osteosynthesis of Diaphyseal Fractures with Massive Metal Pins (Experimental and Clinical Investigation). Doctoral Dissertation, Moscow (1968).Google Scholar
  6. 6.
    M. N. Pavlova and V. A. Landa, Abstracts of Proceedings of a Scientific Conference to Celebrate the 25th Anniversary of Foundation of Kazan' Scientific-Research Institute of Traumatology and Orthopedics [in Russian], Kazan' (1970), p. 33.Google Scholar
  7. 7.
    L. I. Stekol'nikov, O. M. Tepelina, and V. M. Konopatskaya, Biofizika,13, 152 (1968).Google Scholar
  8. 8.
    D. Baylink, E. Morey, et al., Endocrinology,84, 261 (1969).Google Scholar
  9. 9.
    J. Binderman and A. Horell, Israel J. Med. Sci.,7, 369 (1971).Google Scholar
  10. 10.
    L. E. Ericson, J. Ultrastruct. Res.,24, 145 (1968).Google Scholar
  11. 11.
    V. V. Ngiyen and J. Jowsey, J. Bone Joint Surg.,52, 104 (1970).Google Scholar
  12. 12.
    H. Sissons, J. Jowsey, and L. Stewart, in: A. Engstrom and V. Cosslett (editors), X-Ray Microscopy and X-Ray Microanalysis. Proceedings of the 2nd International Symposium, Stockholm (1960), p. 199.Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • V. A. Landa
  • A. I. Briskin

There are no affiliations available

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