Abstract
High concentrations of serotonin, not attributable to the presence of blood in the tissues, were found by the ninhydrin fluorescence method in the bone marrow, lymph glands, and thymus of various species of mammals (dogs, cats, rabbits, guinea pigs, rats, and mice). Administration of exogenous serotonin increased its concentration in the tissues of these organs and also in the spleen. Reserpine sharply lowered the serotonin concentration in these tissues. It is postulated that endogenous serotonin of the hematopoietic and immunocompetent tissues participates in the local regulation of hematopoiesis, immunogenesis, and natural radioresistance. The corresponding effects of exogenous serotonin are probably connected with its direct penetration into the hematopoietic and immunocompetent tissues and to its action on tissue receptors.
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Kulinskii, V.I., Cherkasova, T.I. Serotonin of hematopoietic and immunocompetent tissues of mammals of various species. Bull Exp Biol Med 78, 911–913 (1974). https://doi.org/10.1007/BF00803925
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DOI: https://doi.org/10.1007/BF00803925