Abstract
An increase in the circulating kininogen concentration was found in guinea pigs sensitized with human serum albumin or BCG vaccine. An anaphylactic reaction, subacute in character or manifested as shock with a marked disturbance of respiration, was accompanied by an increase of 1.5–2 times in kallikrein activity and of 6–10 times in plasma kininase activity. The mean decrease in the kininogen concentration was 20–48%, but when the shock followed an acute course it fell by 73–86%. The free kinin concentration was either raised or lowered.
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Literature Cited
T. P. Egorova and T. S. Paskhina, Biokhimiya,32, 354 (1967).
M. S. Surovikina, Byull. Éksperim. Biol. i Med., No. 5, 123 (1971).
M. S. Surovikina, Kardiologiya, No. 2, 119, (1973).
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Surovikina, M.S. Effect of sensitization and anaphylactic shock on the plasma kinin system in guinea pigs. Bull Exp Biol Med 78, 888–889 (1974). https://doi.org/10.1007/BF00803917
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DOI: https://doi.org/10.1007/BF00803917