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Mechanism of changes in the membrane potential in various types of muscle fibers in experimental tetanus

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In early tetanus the fall in membrane potential (MP) of skeletal muscle fibers is nonspecific in character: it is connected with the development of hyperactivity of the muscles, and when this is abolished by division of the nerve, the MP of the skeletal muscle fibers returns to normal. In the late stage of tetanus poisoning the functional properties of the tetanic and tonic muscle fibers are altered to a greater degree than in early tetanus. Administration of ATP, cysteine, and phenylephrine appreciably raises the MP of the poisoned muscle fibers.

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Authors
  1. V. V. Mikhailov
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  2. V. V. Morrison
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Mikhailov, V.V., Morrison, V.V. Mechanism of changes in the membrane potential in various types of muscle fibers in experimental tetanus. Bull Exp Biol Med 78, 871–874 (1974). https://doi.org/10.1007/BF00803912

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  • DOI: https://doi.org/10.1007/BF00803912

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