Participation of the neuro-reflex mechanisms in the pathogenesis of disease produced by in troduction of botulin toxin in the carotid sinus
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The receptor zone of the carotid sinus possesses exceptionally high sensitivity to botulin toxin in connection with which escape from the sinus of extremely small doses of toxin induces death of the animal.
Upon introduction of the toxin in carotid sinus, absence of its escape through the very fine vessels can not be guaranteed. In this connection, disease induced by temporary presence of the toxin in the sinus is the result, not only of the ten minute stimulation of the latter, but of the further prolonged stimulation of the nearest nerve formations by that minimum amount of toxin which penetrates into them from the sinus.
Hemorrhagic affections of the lungs, basic to the syndrome of botulin intoxication appear whatever the method used for introducing the toxin in the organism, including introduction of botulin toxin in the sinus. It may be postulated that the pathogenesis of the affection of the lungs with botulism is associated with the influence of botulin toxin on the vascular-reflexogenic zone of the carotid sinus. Botulin toxin, belonging to the group of vascular-dystrophic poisons, by producing lesion of the vasomotor reflexogenic zones, thereby disturbs the neuro-reflex regulation of the tonus of the vessels, in particular in the lesser blood circulation, which leads to signs of congestion in the lungs.
KeywordsPublic Health Minimum Amount Botulin Toxin Blood Circulation Small Dose
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