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A study of the bacteriostatic and chemotherapeutic activity of the new drug cycloserine

  • Microbiology and Immunity
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Synthetic dl-cycloserine obtained at the Institute of Pharmacology and Chemotherapy of the USSR Academy of Medical sciences was tested in experiments in vitro. It was demonstrated that this preparation has a wide antimicrobic range of action towards gram positive, as well as towards gram negative microbes, such asB. typhi abdominalis,B. paratyphi “A” et al.

Dl-cycloserine has a bacteriostatic effect toward various strains of mycobacterium tuberculosis which are sensitive or resistant to streptomycin, phthivazid and PAS.

It was revealed that this preparation does not show any significant chemotherapeutic effect in experimentally indiced hematogenic tuberculosis in mice and tuberculosis in guinea pigs. However, its toxicity in prolonged administration to guinea pigs is very low. If kept in a thermostat during 8–10 days at a temperature of 37°C the preparation is inactivited by 25 to 30%.

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Authors and Affiliations

  1. Department of Experimental Chemotherapy of the Institute of Pharmacology and Chemotherapy, Acad. Med. Sci. USSR, Moscow

    M. A. Berger, B. Ia. Stukalova & V. S. Mitrofanov

  2. Department of Microbiology of the Institute of Tuberculosis, Acad. Med. Sci. USSR, Moscow

    M. A. Berger, B. Ia. Stukalova & V. S. Mitrofanov

Authors
  1. M. A. Berger
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  2. B. Ia. Stukalova
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  3. V. S. Mitrofanov
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Berger, M.A., Stukalova, B.I. & Mitrofanov, V.S. A study of the bacteriostatic and chemotherapeutic activity of the new drug cycloserine. Bull Exp Biol Med 45, 343–346 (1958). https://doi.org/10.1007/BF00803345

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  • DOI: https://doi.org/10.1007/BF00803345

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