Summary
The activity of blood diaminoxidase is changed under the influence of dimedrol and thiamine, i.e., its activity is either inhibited or, on the contrary enhanced.
It was established in experiments on pigs and cows that different action of dimedrol and thiamine depends on the initial activity of the enzyme. Thus, when the initial activity of diaminoxidase was high thiamine enhanced its activity, while with low initial activity of the enzyme the latter was inhibited by thiamine. The same principle was also experimentally proved in case of dimedrol. The mechanism of increase of diaminoxidase activity under the influence of dimedrol and thiamine is to a certain extent similar to the phenomenon of the “Haldane paradox”.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
V. M. Karasik, Uspekhi Sovremennoi Biol., 20, No. 2, 129–154 (1945).
L. P. Kluga, Biull. Eksptl. Biol. i Med., 36, 4, 41–43 (1953).
J. S. Haldane and J. G. Priestley, Respiration. Moscow-Leningrad, 1937, p. 164 (Russian Translation).
E. A. Zeller, Advances in Enzymology, 1942, v. 2, pp. 93–112.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kluga, L.P. The mechanism of “paradoxical” increase of blood diaminoxidase (histaminase) activity under the influence of dimedrol and thiamine. Bull Exp Biol Med 45, 330–332 (1958). https://doi.org/10.1007/BF00803341
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00803341