Abstract
The ability of HLA sera to react with T and B lymphocytes of human blood was studied. The lymphocytes were separated by removal of one of the cell populations. The method of rosette formation was used, followed by centrifugation in a density gradient and adsorption of B lymphocytes on synthetic fiber. After removal of the B cells the cytotoxic activity of the HLA sera was reduced. Removal of T lymphocytes did not affect the result of the lymphocytotoxic test. It is postulated that B lymphocytes contain more determinants of HLA antigens than T lymphocytes.
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Zotikov, E.A., Tananov, A.T. Difference in the ability of HLA serum to react with T and B lymphocyte populations. Bull Exp Biol Med 81, 865–867 (1976). https://doi.org/10.1007/BF00803005
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DOI: https://doi.org/10.1007/BF00803005