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Disturbance of vascular permeability and the microcirculation during short-term immobilization stress

  • Pathophysiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Immobilization of rats for 1 or 3 h leads to an increase in vascular permeability for ink particles and disturbances of the microcirculation in the mesenteric microvessels (formation of aggregates, appearance of “plasmatic vessels,” closure of arteriolar-venular shunts). An important role in the pathogeneis of these changes is played by histamine liberated from the mast cells without their undergoing degranulation. Liberation of histamine may be the trigger mechanism in the development of disturbances of vascular permeability during prolonged immobilization stress.

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Authors and Affiliations

  1. Academy of Medical Sciences of the USSR, USSR

    A. M. Chernukh

Authors
  1. M. P. Gorizontova
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  2. A. M. Chernukh
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Additional information

Laboratory of General Pathology and Experimental Therapy, Institute of General Pathology and Pathophysiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 6, pp. 645–647, June, 1976.

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Gorizontova, M.P., Chernukh, A.M. Disturbance of vascular permeability and the microcirculation during short-term immobilization stress. Bull Exp Biol Med 81, 796–798 (1976). https://doi.org/10.1007/BF00802981

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  • DOI: https://doi.org/10.1007/BF00802981

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