Bulletin of Experimental Biology and Medicine

, Volume 83, Issue 1, pp 97–100 | Cite as

Physicochemical properties of DNP systems of leukemic cells with different numbers of chromosomes

  • A. I. Svirnovskii
  • V. V. Nikolaichik
  • V. I. Levin
Experimental Genetics


Investigation of the thermomechanical and disaggregation properties of supramolecular DNP systems isolated from leukemic cells revealed a stronger bond than normally between their components. This property of the DNP structures was independent of the subpopulation to which the leukemic cells belonged and of their number of chromosomes (diploid or hyperdiploid sets), i.e., the change in the properties of the chromatin was more specific for leukemic cells than the numerical chromosomal aberrations.

Key Words

leukemia chromatin chromosomes 


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Literature Cited

  1. 1.
    V. V. Nikolaichik and I. P. Kal'vinkovskii, in: Problems in Experimental Genetics, Minsk (1972), pp. 233–242.Google Scholar
  2. 2.
    A. S. Spirin, Biokhimiya, No. 6, 656 (1958).Google Scholar
  3. 3.
    D. M. Spitkovskii, V. T. Andrianov, and A. N. Pisarevskii, Radiation Biophysics of Nucleoprotein [in Russian], Moscow (1969).Google Scholar
  4. 4.
    D. M. Spitkovskii, Vestn. Akad. Nauk SSSR, No. 1, 29 (1973).Google Scholar
  5. 5.
    K. Burton, Biochem. J.,62, 315 (1956).Google Scholar
  6. 6.
    J. Chauveau, G. Moule, and C. Rouiller, Exp. Cell Res.,11, 317 (1956).Google Scholar
  7. 7.
    V. Endo, J. Biochem. (Tokyo),67, 629 (1970).Google Scholar
  8. 8.
    J. H. Frenster, in: The Cell Nucleus (ed. by H. Busch), Vol. 1, Academic Press, New York (1974), pp. 565–580.Google Scholar
  9. 9.
    W. S. Groves, F. C. Davis, and B. H. Sells, Anal. Biochem.,22, 195 (1968).Google Scholar
  10. 10.
    H. Harris, Proc. Roy. Soc. London (Biol.),179, 1 (1971).Google Scholar
  11. 11.
    E. W. Johns, Biochem. J.,104, 78 (1967).Google Scholar
  12. 12.
    O. H. Lowry, N. J. Rosebrough, A. L. Farr, et al., J. Biol. Chem.,193, 265 (1951).Google Scholar
  13. 13.
    J. A. Macpherson, Proc. Roy. Soc. London (Biol.),177, 41 (1971).Google Scholar
  14. 14.
    L. Sachs, Harvey Lect., Series 68 (1972–1973), pp. 1–35.Google Scholar

Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • A. I. Svirnovskii
  • V. V. Nikolaichik
  • V. I. Levin

There are no affiliations available

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