Correction of T-immunodeficiency in mice by bone marrow transplantation from hydrocortisone-treated donors
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B mice were obtained by thymectomy, by lethal irradiation, and by protection of adult CBA mice with syngeneic bone marrow. In some experiments syngeneic bone marrow from donors treated with hydrocortisone in a dose of 125 mg/kg for 3 days was used. Cells carrying the Q marker were determined in the bone marrow of these donors. Thymectomized and lethally irradiated animals injected with bone marrow from donors treated with hydrocortisone rejected skin allografts and lymph node cells from these mice inhibited endogenous colony formation in sublethally irradiated (CBA×C57BL/6)F1 hybrids.
Key wordsB mice cortisone-resistant T lymphocytes endogenous colony formation
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