Experimental influenza caused by an incomplete form of the virus
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An incomplete form of influenza virus obtained by Nayak's method was administered intranasally to CBA and C57BL mice. The pathogenic agent was isolated from the lung tissues of the infected mice for a period of 45 days, but form the other internal organs only during the first few hours after infection. Morphological investigation of the lungs of animals infected with incomplete virus showed predominance of the proliferative component against the background of inflammatory changes. Circumscribed lymphoid structures consisting of monomorphic cells with hyperchromic nuclei were discovered in the lung tissue 3 months after infection. Later, marked proliferation of the alveolar and bronchiolar epithelium was observed, with marked cellular anaplasia in foci of papillomatous growth. Among lesions in other internal organs, glomangiomas of the mesentery were found in 18.7% of the CBA mice.
Key Wordsincomplete influenza virus influenzal pneumonia proliferation of epithelium
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