Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 6, pp 1666–1668 | Cite as

Effect of hydration and dehydration of animals on bioenergetics and mediator processes in neurosecretory cells of the anterior hypothalamus

  • T. A. Mikhailik
Morphology and Pathomorphology


Histochemical methods were used to study the activity of oxidoreductases and enzymes inactivating mediators in the neurosecretory cells of the anterior hypothalamus during hydration and dehydration in rabbits. Enzymes of the Krebs cycle and of the electron transport system were shown to respond by increased activity to dehydration and by reduced activity to hydration. Activity of α-glycerophosphate dehydrogenase and glucose-6-phosphate dehydrogenase was increased compared with the control in both cases. Monoamine oxidase activity was reduced during dehydration but increased during hydration; changes in acetylcholinesterase activity were in the opposite direction.

Key Words

hypothalamus enzymes hydration dehydration 


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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • T. A. Mikhailik

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