Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 6, pp 1651–1653 | Cite as

Development of the response of rabbit fetal tissues to thyroxine

  • N. S. Salakhova
  • S. I. Mirmakhmudova
  • M. Kh. Gainutdinov
  • Ya. Kh. Turakulov
Experimental Biology
  • 11 Downloads

Abstract

The development of the response of rabbit fetal tissues to thyroxine was investigated by determining changes in α-glycerophosphate dehydrogenase activity of the liver mitochondria of pregnant rabbits and their fetuses during administration of thyroxine at different times of pregnancy. Until the 23rd day the activity of this enzyme increased only in the mitochondria of the maternal liver, whereas in the fetuses it remained at the control level. After the 24th day of pregnancy an increase in activity of this enzyme was observed in the fetuses also, where it can be explained by the appearance of the response of the rabbit fetal tissues to maternal thyroxine at this stage of development, and increasing until the end of pregnancy.

Key Words

thyroxine pregnancy α-glycerophosphate dehydrogenase 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    N. B. Andreeva, I. K. Ryvkis, et al., in: The Formation of Endocrine and Metabolic Functions in Newborn Infants in Health and Disease [in Russian], Moscow (1973), pp. 45–46.Google Scholar
  2. 2.
    T. P. Barkhatova, Akush. Ginekol., No. 12, 62 (1968).Google Scholar
  3. 3.
    V. I. Bodyazhina, A. P. Kiryushchenkov, et al., The Side Effects of Drugs [in Russian], Moscow (1970), pp. 57–62.Google Scholar
  4. 4.
    V. N. Nikitin, Age Physiology [in Russian], Leningrad (1975).Google Scholar
  5. 5.
    I. V. Onoprienko, L. A. Lisenko, et al., in: The Formation of Endocrine and Metabolic Functions in Newborn Infants in Health and Disease [in Russian], Moscow (1973), pp. 143–150.Google Scholar
  6. 6.
    N. S. Salakhova, N. M. Mullagalieva, et al., Dokl. Akad. Nauk Uzb. SSR, No. 7, 55 (1975).Google Scholar
  7. 7.
    T. P. Tashkhodzhaeva, N. S. Salakhova, et al., Med. Zh. Uzb., No. 2, 29 (1978).Google Scholar
  8. 8.
    Ya. Kh. Turakulov, N. S. Salakhova, et al., Byull. Éksp. Biol. Med.,83, 563 (1977).Google Scholar
  9. 9.
    D. Kh. Khamidov, A. Abdukarimov, et al., Response of Embryonic Tissues to the Action of Hormones [in Russian], Tashkent (1976).Google Scholar
  10. 10.
    R. E. Beyer, Endocrinology,50, 497 (1952).Google Scholar
  11. 11.
    A. Erenberg, K. Omori, et al., Pediat. Res.,8, 783 (1974).Google Scholar
  12. 12.
    I. M. Freedberg et al., N. Engl. J. Med.,256, 505 (1957).Google Scholar
  13. 13.
    Y.-P. Lee, A. E. Takemori, and H. Lardy, J. Biol. Chem.,234, 3051 (1959).Google Scholar
  14. 14.
    O. H. Lowry, et al., J. Biol. Chem.,193, 265 (1951).Google Scholar
  15. 15.
    P. V. Tishler et al., Enzyme,20, 349 (1975).Google Scholar
  16. 16.
    W. C. Schneider, J. Biol. Chem.,176, 259 (1948).Google Scholar
  17. 17.
    E. P. Williams et al., Arch. Neurol.,29, 145 (1973).Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • N. S. Salakhova
  • S. I. Mirmakhmudova
  • M. Kh. Gainutdinov
  • Ya. Kh. Turakulov

There are no affiliations available

Personalised recommendations