Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 6, pp 1645–1647 | Cite as

Frequency, times, and type of metastasization of transplantable tumors in mice

  • A. M. Kozlov
  • Z. P. Sof'ina
Oncology
  • 14 Downloads

Abstract

The character of metastasization of nine strains of transplantable mouse tumors injected by the usual subcutaneous method was studied. Differences were observed in the frequency, intensity, and types of metastasization of different tumors. Latent periods of onset of metastases of Lewis and RL-67 lung carcinomas and of sarcoma-37 were determined. Sarcoma-37, Lewis and RL-67 carcinomas of the lung, AKATOL adenocarcinoma of the large intestine, and Cloudman's and B-16 melanomas metastasized most intensively. Sarcoma-37, metastasizing into the lungs, RL-67 lung carcinoma metastasizing into the lungs, kidneys, adrenals, ovaries, and heart, and adenocarcinoma of the large intestine AKATOL, forming metastases in the lymph nodes and liver, can be used as models for seeking methods of chemotherapeutic action on metastases and metastasization.

Key Words

transplantable tumors metastasization 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    I. F. Grekh, in: Proceedings of a Conference on the Use of Pyrimidine Derivatives in Oncology and in Other Fields of Medicine [in Russian], Leningrad (1963), p. 27.Google Scholar
  2. 2.
    I. F. Grekh and V. Ya. Shats, Vopr. Onkol., No. 1, 57 (1966).Google Scholar
  3. 3.
    N. S. Kiseleva, Pat. Fiziol., No. 4, 50 (1962).Google Scholar
  4. 4.
    N. S. Kiseleva, “Experimental models of metastasization of tumors,” Author's Abstract of Doctoral Dissertation, Moscow (1972).Google Scholar
  5. 5.
    Yu. N. Mol'kov, Vopr. Onkol., No. 9, 19 (1960).Google Scholar
  6. 6.
    N. R. Myuller, E. V. Tsirlina, M. N. Ostroumova, et al., Vopr. Onkol., No. 7, 86 (1975).Google Scholar
  7. 7.
    R. N. Pelyukhova, Vopr. Onkol., No. 9, 80 (1976).Google Scholar
  8. 8.
    E. B. Sapotsinskaya, Vrach. Delo, No. 12, 102 (1973).Google Scholar
  9. 9.
    K. V. Yaremenko, in: Current Problems in Oncology [in Russian], Leningrad (1967), p. 59.Google Scholar
  10. 10.
    C. B. Skov, J. M. Holland, and E. H. Perkins, J. Natl. Cancer Inst.,56, 193 (1976).Google Scholar
  11. 11.
    L. Dobrossy, Europ. J. Cancer,3, 531 (1968).Google Scholar
  12. 12.
    M. Kadama and T. Kadama, Cancer Res.,35, 1015 (1975).Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • A. M. Kozlov
  • Z. P. Sof'ina

There are no affiliations available

Personalised recommendations